What should be monitored closely in patients using nonopioid analgesics?

In patients using nonopioid analgesics, particularly those that fall in the category of nonsteroidal anti-inflammatory drugs (NSAIDs), monitoring liver function is important. Many nonopioid analgesics, especially those containing acetaminophen (paracetamol), can have hepatotoxic effects when taken in excessive doses or used over prolonged periods. The liver metabolizes these drugs, and liver function tests can reveal abnormalities that indicate potential liver damage or impairment.

Additionally, certain nonopioid analgesics can interact with other medications that are metabolized by the liver, exacerbating any existing liver issues. Thus, clinicians pay close attention to liver enzyme levels, which can help in assessing the safety and effectiveness of the analgesic therapy, ensuring that any signs of liver distress are identified early.